The filter function results in the indications valid in conventional medicine (see end of the newsletter), which are mostly used in intensive care medicine in exceptional situations. In recent years, its use has increasingly spread to private clinics and practices. The spread and popularity of double filtration plasma apheresis can be attributed to the successes of the nephrologist Dr. Straube in Cham, Germany. He significantly expanded the indication and showed that even smaller molecules such as heavy metals or almost all toxins can be filtered out in certain quantities during plasma apheresis.